During a significant 55% increase in chikungunya cases this year, the health department plans to carry out genetic sequencing of samples to identify potential mutations. Uncommon symptoms like hyperpigmentation and neurological issues have been reported. In light of the nearly 55% surge in chikungunya cases compared to last year, the health department in Mumbai intends to analyze select positive samples to detect any genetic changes in the virus. Officials clarified that newly observed symptoms like hyperpigmentation and neurological problems (inflammation in the brain or heart tissues) are rare occurrences and may be linked to co-infections with dengue or Japanese encephalitis. A rapid action team has been established to investigate the reasons behind the rise in chikungunya cases from 1,702 in 2023 to 2,643 in 2024 so far. Guidelines have been issued for the collection and analysis of samples by both the National Institute of Virology and B J Medical College in Pune. Specifically, samples from patients displaying neurological symptoms such as paralysis and hyperpigmentation are to be sent for further assessment, including genomic sequencing. This process aims to identify any mutations in the virus. Dr. Rajesh Karyakarte from B J Medical College explained that genomic sequencing will provide insights into potential mutations and aid in understanding the virus better."Start sequencing as soon as we receive enough samples, particularly from patients in the intensive care unit or with severe symptoms," he stated. Private sector doctors in the city reported a significant increase in chikungunya cases this year, with some patients requiring hospitalization to manage high fever for 10 to 15 days and address neurological complications. Children have also been disproportionately affected this year, as evidenced by the admission of an eight-month-old boy to SRCC Children's Hospital in Haji Ali in early August. At Surya Children's Hospital in Santa Cruz, pediatrician Dr. Bhupendra Avasthi noted that children born to mothers who tested positive for chikungunya display hyperpigmentation as a symptom, which is a well-documented characteristic of the disease."